Duvauchelle starred in numerous movies including Lightweight, À tout de suite and Le Grand Meaulnes. He has worked with Beatrice Dalle on films such as Trouble Every Day, Inside and Djinns.

In production for Duvauchelle is his first English-speaking feature length presentation, tentatively titled You Better Be Good To Me starring Irish actress Roisin Browne, detailing the life and obsession of a woman in love. Set in Belfast, and with featured credit from an unknown artist labelled within the industry as 'Tin-tin', Duvauchelle commented to Empire magazine that he was 'excited about his first English picture and pleased at the chance to work alongside an actress as versatile as Browne.' Filming is set to start on June 2008.

He is the father of Bonnie Sagnier and ex-partner of actress, Ludivine Sagnier.